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N-acetyltransferase 2 mutation status (genetic analysis)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic variations in the N-acetyltransferase 2 (NAT2) gene, which can influence how your body processes certain medications and toxins.

Quick summary

["Understanding your NAT2 gene variant may help tailor medication choices for better safety and effectiveness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101141-0
Short code
NAT2 Mut Anl Bld/T
Synonyms
NAT2 Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you’re considering medications that are metabolized by NAT2, such as certain anticonvulsants, antibiotics, or drugs for tuberculosis. It’s also used in research or genetic counseling for conditions linked to NAT2 variants.

What to Expect Before the Test

No special preparation is needed. If blood is drawn, you may experience mild discomfort, but it’s a quick procedure. If saliva is used, simply spit into a collection tube.

What the Results Mean

Results identify whether you carry specific NAT2 gene mutations. These variants can affect how quickly your body breaks down drugs or toxins, which may influence dosing or monitoring needs.

Common Medications Affected

Medications like isoniazid (for TB), sulfonamides (antibiotics), and some antiepileptics may interact differently based on your NAT2 variant. Your provider will discuss how this might affect your treatment plan.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

NAT2 Mutation Test

Frequently asked questions

Will this test affect my current medications?
Possibly. Your provider will review your results with you to determine if your medication regimen needs changes, especially for drugs metabolized by NAT2.
How long will I need to wait for results?
Results may take several days to a couple of weeks, depending on the lab and testing method. Your provider will contact you once they’re ready.
Can I get this test if I’m pregnant or breastfeeding?
Yes, but your provider will weigh the benefits and risks based on your situation. Genetic testing is generally safe, but always discuss this with your healthcare team.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy