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Norepinephrine (serum/plasma concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of norepinephrine, a key chemical in your body that helps regulate your heart rate, blood pressure, and response to stress.

Quick summary

["Norepinephrine helps control your body’s fight-or-flight response and blood pressure levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54078-1
Short code
NB pnl CF Patient
Synonyms
NB pnl CF Patient
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like high blood pressure, rapid heartbeat, anxiety, or signs of low blood pressure (such as dizziness or fainting). It can also be used to evaluate conditions affecting your nervous system, like certain types of shock or nerve disorders.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for a few hours before the test if it’s drawn from your blood. If you’re taking medications, let your healthcare provider know beforehand.

How the Test Works

A small sample of blood is taken from a vein in your arm. The blood is then sent to a lab to measure norepinephrine levels using a sensitive detection method, often an immunoassay.

What the Results Mean

Results can vary based on your health, medications, and other factors. High levels may suggest conditions like pheochromocytoma (a tumor affecting hormone production) or severe stress. Low levels might indicate nerve damage or certain medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated norepinephrine levels can indicate overactivity of the sympathetic nervous system, potentially linked to conditions such as hypertension, heart disease, or adrenal tumors. Lower levels may reflect autonomic dysfunction or certain neurological disorders. Always discuss results with your healthcare provider for personalized interpretation.

Short name

Norepinephrine Level

Frequently asked questions

What causes high norepinephrine levels?
High norepinephrine levels can be caused by conditions like pheochromocytoma (a tumor that releases excess hormones), severe stress or trauma, certain medications (e.g., some antidepressants), or nerve-related disorders. Your doctor will review your symptoms and medical history to determine the cause.
What does it mean if my norepinephrine is low?
Low norepinephrine levels may suggest nerve damage (neuropathy), certain medications affecting nerve function, or conditions like autonomic dysreflexia. If you experience symptoms like dizziness or fainting, talk to your doctor about further evaluation.
Can I eat or drink before this test?
Most often, no special diet is required, but if your doctor instructed fasting, follow their guidance. Avoid caffeine or alcohol before the test, as they can affect blood pressure and may influence results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy