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Nuclear Factor Erythroid 2–Related Factor 2 (NFE2L2) Protein, Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of NFE2L2 protein, a key regulator involved in protecting cells from oxidative stress and maintaining healthy metabolism.

Quick summary

["Understanding your NFE2L2 protein levels may help assess how your body handles oxidative damage or metabolic health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101965-2
Short code
NDUFAF5 Mut Anl Bld/T
Synonyms
NDUFAF5 Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

NFE2L2 (also called NRF2) is a protein that helps cells respond to harmful substances, such as pollutants or excess free radicals. Your test result reflects its concentration in your blood, which can vary based on health status, diet, or exposure to certain conditions.

Why It Might Be Ordered

Doctors may order this test if you have symptoms or conditions linked to oxidative stress (e.g., chronic fatigue, metabolic disorders) or if you’re being evaluated for genetic or metabolic syndromes that involve NRF2 pathways.

Common Conditions Monitored

While not routinely checked for most conditions, elevated or altered NFE2L2 levels could be investigated in cases of suspected oxidative stress disorders, certain metabolic diseases, or as part of broader genetic testing for conditions affecting cellular protection mechanisms.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in the arm. The sample is collected in a tube that separates serum (liquid part) or plasma (whole blood minus clotting factors) for testing. Avoid strenuous activity or eating for 12 hours before the test to ensure accurate results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

NFE2L2 Protein Level

Frequently asked questions

How might my NFE2L2 levels affect my health?
NFE2L2 plays a role in activating genes that protect cells from oxidative damage. Abnormal levels may suggest underlying metabolic or genetic conditions, but results alone don’t diagnose specific diseases. Your doctor will interpret results in the context of your symptoms and medical history.
What do abnormal results mean?
Elevated levels might indicate conditions where oxidative stress is heightened, such as certain metabolic disorders or genetic mutations. Lower-than-expected levels could be associated with conditions affecting cellular protection mechanisms, but further testing and evaluation are needed to clarify.
Do diet or lifestyle changes affect NFE2L2 levels?
Yes, diet, exercise, and exposure to toxins (e.g., air pollution) can influence NFE2L2 activity. Antioxidant-rich foods or supplements may support healthy levels, but results should be reviewed with your healthcare provider for personalized advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy