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Neurofilament Light Chain (NfL) in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures levels of neurofilament light chain, a protein found in nerve cells. It helps assess nerve damage or disease progression in the brain and spinal cord.

Quick summary

["NFL blood tests may help track conditions affecting nerves over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101452-1
Short code
Neurochondrin Ab SerPl Ql IF
Synonyms
Neurochondrin Ab SerPl Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms of nerve damage, such as weakness, numbness, or balance issues. It’s also used in research or monitoring conditions like multiple sclerosis, traumatic brain injury, or neurodegenerative diseases.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. The sample is sent to a lab for analysis using advanced techniques like mass spectrometry or immunoassay.

What to Expect Before or After the Test

No special preparation is needed, but avoid strenuous activity 24 hours before. Results may take several days to weeks, depending on lab processes.

What Are Possible Results?

Results are often reported as a numerical value representing protein concentration. Higher levels may suggest nerve damage or disease activity, but interpretation depends on clinical context and your symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

NFL Blood Test

Frequently asked questions

How often is this test used in routine care?
This test is primarily used in specialized settings, such as research studies or advanced clinical assessments, rather than routine care. It’s not typically ordered for general health checks.
What symptoms might lead to this test?
Symptoms like progressive weakness, vision changes, or balance problems—especially if unexplained—may prompt a doctor to consider this test, particularly in patients with suspected nerve or brain disorders.
Does this test require fasting?
No fasting is required for this blood test. However, always follow your doctor’s instructions for any specific preparation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy