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Neurofascin-140 Antibody Screening (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against neurofascin-140, a protein involved in nerve cell signaling. It may be used to investigate conditions affecting nerve function or autoimmune responses in the nervous system.

Quick summary

["This screening helps identify potential immune-related nerve disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106740-4
Short code
Neurofascin-140 Ab Ser Ql CBA IFA
Synonyms
Neurofascin-140 Ab Ser Ql CBA IFA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like numbness, weakness, or other neurological issues that could be linked to an autoimmune attack on nerve proteins. It may also be part of a broader evaluation for conditions such as Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, or other neuromuscular disorders.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from your arm. The test involves a simple venipuncture procedure, and you may feel a slight pinch or discomfort for a few seconds.

What the Results Mean

Results are qualitative (positive or negative). A positive screening result suggests the presence of antibodies against neurofascin-140, which may warrant further diagnostic testing to explore underlying causes.

Common Conditions This Test Helps Diagnose

While not all positive results indicate a specific diagnosis, this test can support the evaluation of autoimmune neuropathies or conditions where the immune system mistakenly targets nerve proteins.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Neurofascin-140 is a critical protein in nerve cell connections. Antibodies against it may disrupt normal nerve signaling, potentially leading to symptoms like muscle weakness, sensory loss, or autonomic dysfunction. This test helps identify whether an immune-mediated process is affecting these nerves, guiding further treatment or management strategies.

Short name

Neurofascin-140 Antibody Screen

Frequently asked questions

What Does a Positive Result Indicate?
A positive screening result means your blood contains antibodies against neurofascin-140. This finding may suggest an autoimmune process affecting nerves, but it does not confirm a specific diagnosis. Follow-up testing, such as additional antibody panels or nerve function studies, may be needed to explore potential causes.
Can This Test Be Used to Monitor Treatment?
Yes, if this test is part of a diagnostic workup for a suspected autoimmune neuropathy, results may be monitored over time to assess response to treatment. However, further clinical correlation is required to determine if changes in antibody levels correlate with improvements or worsening of symptoms.
Are There Any Risks or Side Effects?
The most common risk is mild discomfort or bruising at the needle insertion site. Rarely, there may be a slight reaction to the blood draw, such as swelling or redness. Most side effects are minor and resolve quickly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy