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Neurofascin-155 Antibody, Serum (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test measures whether your body produces antibodies against neurofascin-155, a protein involved in nerve cell connections. It may be used to help diagnose or monitor certain autoimmune or neurological conditions.

Quick summary

["This test helps identify immune responses linked to nerve-related disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106739-6
Short code
Neurofascin-155 Ab Ser Ql CBA IFA
Synonyms
Neurofascin-155 Ab Ser Ql CBA IFA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions associated with abnormal nerve signaling, such as chronic pain, muscle weakness, or neurological disorders. It could also be part of an evaluation for conditions like Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, or other autoimmune neuropathies.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from a vein in your arm. The test involves a small needle, and you may feel a brief pinch. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Positive results indicate the presence of antibodies against neurofascin-155, suggesting an immune-mediated process affecting nerve function. Negative results mean no detectable antibodies were found in this sample. Interpretation depends on your clinical symptoms and overall health.

Common Conditions Monitored

This test is often used to support a diagnosis of autoimmune neuropathies, such as those linked to Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, or other nerve-related autoimmune disorders. It may also be part of a broader evaluation for unexplained neurological symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Antibodies Against Neurofascin-155

Short name

Neurofascin-155 Antibody Test

Frequently asked questions

What are the possible causes of abnormal antibody levels in this test?
Abnormal antibody levels may be associated with autoimmune diseases that target nerve cells, such as Guillain-Barré syndrome or chronic inflammatory demyelinating polyneuropathy. These conditions occur when the immune system mistakenly attacks healthy nerve tissues. Other possible causes include rare genetic predispositions or exposure to environmental triggers that provoke an immune response.
How might my results affect my treatment plan?
If your results show elevated antibodies, your healthcare provider may adjust your treatment to focus on managing the underlying autoimmune process. This could include medications to suppress the immune system, physical therapy, or other interventions tailored to your symptoms. Follow-up testing may also be recommended to monitor changes over time.
Can this test be used to diagnose a specific condition?
While this test can help identify an immune response against neurofascin-155, it is not a standalone diagnostic for conditions like Guillain-Barré syndrome. Doctors typically use it alongside other clinical findings, physical exams, and possibly additional tests (such as nerve conduction studies or spinal fluid analysis) to make a diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy