Skip to content

Neurofascin-186 Antibody, Serum (Qualitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of antibodies against neurofascin-186, a protein involved in nerve cell signaling. It may be used to evaluate conditions affecting nerve function or autoimmune responses in the nervous system.

Quick summary

["This test helps identify potential autoimmune or inflammatory conditions affecting nerve cells."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106741-2
Short code
Neurofascin-186 Ab Ser Ql CBA IFA
Synonyms
Neurofascin-186 Ab Ser Ql CBA IFA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like numbness, weakness, or other neurological issues that could suggest nerve damage or an autoimmune disorder targeting nerve proteins. It may also be part of a broader evaluation for conditions like Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, or other neuropathies linked to antibody-mediated damage.

What to Expect Before the Test

No special preparation is typically needed. You may have a small needle inserted into a vein (usually in your arm) to draw a blood sample. If you’re nervous, let your healthcare provider know—they can help make the process more comfortable.

What the Test Results Mean

A positive result indicates the presence of antibodies against neurofascin-186, which may suggest an autoimmune response affecting nerves. A negative result means no detectable antibodies were found in this sample. Results should always be interpreted by a healthcare provider in the context of your symptoms and medical history.

Common Conditions This Test Helps Diagnose

This test is often used to support a diagnosis of autoimmune neuropathies, such as those linked to anti-MOG (myelin-associated glycoprotein) or anti-NF186 syndromes. It may also be part of a workup for other neurological conditions where nerve-specific antibodies are suspected.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

Neurofascin-186 Antibody Test

Frequently asked questions

Will this test affect my treatment?
Not directly. This is a screening or confirmatory test to help guide further evaluation or treatment decisions. If your results suggest an autoimmune-related issue, your healthcare provider may recommend additional tests or therapies tailored to your condition.
How often will I need this test?
Frequency depends on your symptoms and treatment plan. Some patients may need retesting periodically if they’re on long-term immunosuppressive therapy or if their condition is monitored closely.
What if my results are abnormal?
If your test shows antibodies against neurofascin-186, your provider may recommend further testing (like MRI, nerve conduction studies, or other antibody panels) to narrow down the cause. Treatment could include medications to reduce inflammation, immune-modulating therapies, or other interventions based on your specific diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy