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Neutrophil count with differential (serum/plasma mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the absolute number of neutrophils in your blood and evaluates their proportion among all white blood cells.

Quick summary

["Neutrophils help fight infections, and this test helps assess immune response and blood health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
85377-0
Short code
Neut PMA DHR/Neut PMA NFr Cont Bld FC
Synonyms
Neut PMA DHR/Neut PMA NFr Cont Bld FC
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Neutrophils Do in Your Body

Neutrophils are a type of white blood cell that play a key role in fighting bacterial infections. They move quickly to areas of infection, where they destroy bacteria and release chemicals to control inflammation. This test helps doctors understand how well your immune system is responding to infections or other conditions that may affect neutrophils.

How the Test Works

Blood is drawn from a vein, usually in your arm. The sample is then analyzed to count neutrophils and determine their relative numbers compared to other white blood cells. The results help identify if your neutrophil count is too high or too low, which can signal different health concerns.

When You Might Need This Test

Doctors may order this test if you have symptoms like frequent infections, fever, fatigue, or if you’re recovering from surgery, chemotherapy, or a serious illness. It can also be used to monitor conditions like leukemia, autoimmune diseases, or infections.

What the Results Mean

Results are typically expressed as absolute neutrophil counts (ANC) and percentages of neutrophils among all white blood cells. High neutrophil counts may indicate infection, inflammation, or stress, while low counts can signal immune suppression, certain cancers, or blood disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Neutrophil profile

Frequently asked questions

Why might my doctor want to check this?
Your doctor may recommend this test to diagnose or monitor conditions affecting your immune system, such as infections, blood disorders, or autoimmune diseases. It can also help guide treatment decisions for conditions like cancer or chronic illnesses.
What are normal results?
There are no specific ranges provided here since they vary by lab and individual health. Your doctor will interpret results in relation to your overall health and symptoms. Low or high counts may need further investigation.
Can I prepare for this test?
No special preparation is needed, but avoid strenuous activity or eating heavy meals 24 hours before the test. If you’re on certain medications, let your doctor know.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy