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Absolute Neutrophil Count (Manual Cell Differentiation)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your blood. Neutrophils help fight infections.

Quick summary

["Neutrophils are key defenders against bacterial infections; their count helps assess immune health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100850-7
Short code
Neutrophils # Amn Manual
Synonyms
Neutrophils # Amn Manual
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to check for infections, blood disorders, or immune system issues. It can also help evaluate conditions like leukemia, autoimmune diseases, or chronic inflammation.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or vein for a blood draw. The process usually takes a few minutes.

How the Test Works

Blood is drawn and examined under a microscope by a trained technician. Neutrophils are counted manually to ensure accuracy, especially in cases where automated methods might miss subtle changes.

What the Results Mean

Results show the absolute number of neutrophils per microliter of blood. High counts may indicate infections, inflammation, or other conditions. Low counts can signal immune deficiencies or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Elevated neutrophil counts often point to acute infections, stress responses, or inflammatory diseases. Low counts may suggest immune disorders, bone marrow problems, or severe infections requiring urgent medical attention. Always discuss results with your healthcare provider.

Short name

Neutrophil Count

Frequently asked questions

What causes a high neutrophil count?
Common causes include bacterial infections, severe illness, stress, or certain medications. Chronic conditions like rheumatoid arthritis or inflammatory bowel disease may also raise neutrophil levels.
What causes a low neutrophil count?
Low neutrophil counts can result from infections, autoimmune diseases, chemotherapy, or bone marrow disorders. Rarely, genetic conditions or vitamin deficiencies may play a role.
Can diet affect neutrophil counts?
Dietary factors like vitamin deficiencies (e.g., B12, folate) or excessive alcohol may indirectly impact immune function, but they don’t directly alter neutrophil counts. Focus on a balanced diet to support overall health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy