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Neutrophil Count in Cerebrospinal Fluid (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your cerebrospinal fluid (CSF). It helps assess conditions affecting the brain and spinal cord.

Quick summary

["Neutrophils in CSF can signal inflammation or infection in the central nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
754-2
Short code
Neutrophils # CSF Auto
Synonyms
Neutrophils # CSF Auto
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms like severe headaches, neck stiffness, fever, confusion, or neurological issues. It’s often used to check for conditions such as meningitis, brain infections, or other inflammatory diseases in the central nervous system.

What to Expect Before the Test

You’ll likely have a lumbar puncture (spinal tap) where a small needle is inserted into your lower back to collect CSF. The procedure is usually quick and may cause mild discomfort. No special preparation is needed, but inform your doctor about any medications or allergies.

What the Results Mean

High neutrophil counts in CSF often indicate an infection (e.g., bacterial meningitis) or severe inflammation. Low or normal counts may suggest viral infections, autoimmune conditions, or other non-infectious causes. Results are interpreted by your doctor based on your symptoms and medical history.

Common Conditions Linked to Abnormal Results

Elevated neutrophils in CSF are commonly associated with bacterial meningitis, subarachnoid hemorrhage, or certain brain abscesses. Lower-than-normal counts might suggest viral meningitis, multiple sclerosis, or other neurological disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Neutrophils

Frequently asked questions

How often will I need this test?
The frequency depends on your symptoms and diagnosis. Your doctor may order it once or repeatedly if your condition requires ongoing monitoring.
Can I eat or drink before the test?
No special diet is required, but avoid caffeine or heavy meals 2 hours before the procedure to reduce discomfort during the lumbar puncture.
What are the risks or side effects of this test?
Risks include mild headaches, bruising, or temporary nerve pain. Rarely, complications like infection or nerve damage may occur, but serious risks are uncommon with proper medical supervision.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy