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Absolute Neutrophil Count (from Cerebrospinal Fluid)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your cerebrospinal fluid (CSF). Neutrophils help fight infections.

Quick summary

["Neutrophils in CSF can signal inflammation or infection in the brain or spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26512-4
Short code
Neutrophils NFr CSF
Synonyms
Neutrophils NFr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is a Neutrophil Count in CSF Used For?

Doctors may order this test to investigate symptoms like severe headaches, neck stiffness, fever, or neurological issues that could indicate conditions such as meningitis, brain abscesses, or other infections. It helps determine if there’s an abnormal immune response in the central nervous system.

When Might You Need This Test?

You might need this test if you have signs of infection or inflammation in the brain or spinal cord, such as persistent headaches, confusion, or a history of neurological problems. It’s also used in monitoring certain conditions like multiple sclerosis or after head injuries.

How Is the Test Performed?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then examined under a microscope to count the neutrophils. This test is usually done in a hospital or clinic setting.

What Are Possible Results?

Results are reported as the number of neutrophils per microliter (µL) of CSF. A high count (elevated neutrophils) often suggests infection or inflammation, while a normal count helps rule out these conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Neutrophil count in CSF

Frequently asked questions

Why is this test important?
This test helps doctors diagnose infections like bacterial meningitis, viral meningitis, or other inflammatory conditions in the central nervous system. It can also guide treatment decisions, such as starting antibiotics for bacterial infections.
What does an elevated neutrophil count mean?
An elevated neutrophil count in CSF typically indicates an active infection or inflammatory process, such as bacterial meningitis. However, other conditions like brain tumors or certain autoimmune diseases can also cause changes in CSF cell counts.
Can this test be done at home?
No, this test requires a medical procedure called a lumbar puncture, which is performed in a hospital or clinic by a healthcare professional. It’s not a routine at-home test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy