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Neutrophil count (qualitative or semi-quantitative manual differential count)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates the proportion of neutrophils, a type of white blood cell, in your blood. It helps assess immune function and identify conditions like infections or inflammatory diseases.

Quick summary

Neutrophils are key to fighting infections; this test helps track their levels manually for detailed analysis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71658-9
Short code
Neutrophils NFr.DF CSF Manual
Synonyms
Neutrophils NFr.DF CSF Manual
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like frequent infections, fever, or signs of inflammation. It’s also used to monitor conditions like leukemia, autoimmune diseases, or chronic infections.

What to Expect Before the Test

No special preparation is needed, but avoid strenuous activity or infections before the blood draw. Fasted or non-fasted states don’t typically affect this manual count.

How the Test Works

A small blood sample is drawn, and a trained technician manually examines the cells under a microscope. Neutrophils are counted relative to other white blood cells.

What the Results Mean

Results are qualitative or semi-quantitative, showing the percentage of neutrophils compared to other white blood cells. Abnormal proportions may suggest immune disorders or infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Neutrophils are the body’s first responders to infections. Elevated counts may indicate acute bacterial infections, while low counts can signal immune deficiencies or certain cancers. This manual differential helps refine diagnosis when automated counts are inconclusive.

Short name

Neutrophil Differential (Manual)

Frequently asked questions

What causes a manual neutrophil differential to be ordered?
Your doctor may order this test if standard blood tests show unusual white blood cell counts, if you have symptoms like persistent fevers or unexplained infections, or if you’re being evaluated for conditions like neutropenia or leukemia.
How long does it take to get results from this test?
Results are typically available within 24 to 48 hours, as this is a manual process performed by a trained lab technician.
Does fasting affect neutrophil counts from this test?
No, fasting does not influence neutrophil counts in this manual differential test. However, avoid infections or extreme physical activity before the blood draw.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy