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Neutrophil count (qualitative or semi-quantitative manual differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your blood. Neutrophils help fight infections.

Quick summary

Neutrophils are key defenders against bacterial infections; their count helps assess immune health.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71616-7
Short code
Neutrophils NFr.DF Plr Manual
Synonyms
Neutrophils NFr.DF Plr Manual
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate your immune system, check for infections, or monitor conditions like inflammation or certain blood disorders. It can also help diagnose or manage conditions such as leukemia, autoimmune diseases, or infections.

What to Expect Before the Test

No special preparation is needed. You may have a simple blood draw from a vein in your arm. If you’re concerned about discomfort, let your provider know.

What Happens During the Test?

A healthcare professional will draw a small amount of blood. The sample is then examined under a microscope by a trained technician to count neutrophils manually. Results are qualitative (qualitative) or semi-quantitative (approximate) rather than precise numbers.

What Does the Test Result Mean?

Results are interpreted based on your clinical picture. High neutrophil counts may indicate infections, inflammation, or stress. Low counts could suggest immune suppression, certain cancers, or other conditions. Your provider will discuss findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Neutrophils play a critical role in fighting bacterial infections. Elevated counts often signal active infection or inflammation, while decreased counts may indicate immune dysfunction or bone marrow disorders. This test is a key part of diagnosing and managing infectious diseases, autoimmune disorders, and blood-related conditions.

Short name

Neutrophil count (manual)

Frequently asked questions

What does a ‘manual’ neutrophil count mean?
A manual neutrophil count means the blood sample is examined under a microscope by a technician who counts neutrophils directly. This method provides a qualitative or semi-quantitative result, not a precise numeric count. It’s useful for general assessment but may not be as detailed as automated tests.
Why might my provider choose a manual neutrophil count over an automated one?
Manual counts are often used when quick, qualitative results are needed, such as in emergency settings or when resources are limited. They may also be preferred for certain clinical scenarios where detailed white blood cell differentiation is important, like in diagnosing infections or autoimmune conditions.
Can this test be done on other body fluids besides blood?
No, this test is performed on whole blood. Neutrophils are white blood cells found in circulation, so they are best measured in blood samples.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy