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Neutrophil count (qualitative or semi-quantitative manual differential)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates the proportion of neutrophils, a type of white blood cell, in your blood using a manual microscopic examination.

Quick summary

Neutrophils help fight infections; this test checks their presence and relative numbers.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71635-7
Short code
Neutrophils NFr.DF Prt Manual
Synonyms
Neutrophils NFr.DF Prt Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test to assess immune function, diagnose infections, or evaluate conditions affecting white blood cells, such as certain blood disorders or inflammatory diseases.

How the Test Works

A small sample of your blood is examined under a microscope by a trained technician. Neutrophils are counted and compared to other white blood cell types to determine their relative proportion.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your vein (usually in your arm) to draw blood. This is typically done in a clinic or hospital setting.

What to Expect During the Test

You may feel a brief pinch or discomfort when the needle is inserted, but it usually only takes a few minutes. Afterward, you can resume normal activities.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High neutrophil counts may indicate acute infections, inflammation, or other conditions like leukemia. Low neutrophil counts can signal immune deficiencies, bone marrow disorders, or certain medications affecting white blood cell production.

Short name

Neutrophil count (manual differential)

Frequently asked questions

What does a high neutrophil count mean?
A high neutrophil count often suggests an active infection, such as a bacterial infection, or an inflammatory process in your body. It can also be seen in conditions like rheumatoid arthritis or other autoimmune disorders.
What does a low neutrophil count mean?
A low neutrophil count may indicate an immune deficiency, where your body struggles to fight infections effectively. It can also be caused by certain medications, chemotherapy, or conditions affecting the bone marrow.
How often should I get this test?
The frequency depends on your medical condition and healthcare provider’s recommendations. Some patients may need this test regularly if they have chronic conditions like certain blood disorders or autoimmune diseases.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy