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Neutrophil count (qualitative manual differential blood smear)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates the proportion of neutrophils, a type of white blood cell, by examining a blood smear under a microscope. It helps assess immune function and detect conditions like infections or inflammation.

Quick summary

["Neutrophils are key defenders against bacterial infections; abnormal counts may signal health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
759-1
Short code
Neutrophils # Prt Manual
Synonyms
Neutrophils # Prt Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to diagnose or monitor conditions such as infections (e.g., bacterial), inflammatory diseases, or blood disorders. It can also help evaluate immune responses or guide treatment decisions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted to draw blood from a vein, usually in your arm. The process takes a few minutes, and you may feel a brief pinch.

How the Test Results Are Interpreted

Results are qualitative (not a specific number) and describe the percentage of neutrophils relative to other white blood cells. High neutrophil counts may indicate infection or stress, while low counts could signal immune suppression or other conditions.

Potential Risks and Considerations

The most common risk is a minor bruise or slight discomfort at the needle site. Rarely, blood tests can cause allergic reactions or fainting. If you have bleeding disorders or take blood thinners, inform your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Neutrophil count (manual)

Frequently asked questions

What does a high neutrophil count mean?
A high neutrophil count may signal an active bacterial infection, severe inflammation, or stress (e.g., from illness or trauma). Your doctor will consider your symptoms and other test results to determine the cause.
Is this test different from a full blood count (CBC)?
Yes. While a CBC provides overall white blood cell counts, this test focuses specifically on neutrophils by examining a blood smear under a microscope. Both tests are used together for a complete picture of your immune health.
Can I eat or drink before this test?
No special diet is needed. You can eat and drink normally, but avoid caffeine or heavy meals right before the blood draw if your doctor specifies otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy