Neutrophil Count (Blood) by Manual Cell Differentiation

Why This Test Might Be Ordered

Your healthcare provider may order this test to check for infections, such as bacterial infections, or to monitor conditions like chronic inflammation, autoimmune diseases, or certain cancers. It can also help assess how well your immune system is responding to treatment.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it involves drawing blood from a vein, but this depends on your provider’s instructions. Bring any medications or supplements you’re taking to your appointment.

What Happens During the Test

A healthcare professional will draw a small amount of blood from a vein in your arm using a needle. The blood sample is then examined under a microscope by a trained technician to count neutrophils and other white blood cells manually.

What the Results Mean

Results show the absolute neutrophil count (ANC), which is the number of neutrophils per microliter of blood. Low counts may indicate infections, immune disorders, or certain medications. High counts could signal infections, inflammation, or other conditions. Your provider will interpret results in the context of your overall health.