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Neutrophil Count in Cerebrospinal Fluid (Manual Cell Differentiation)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your cerebrospinal fluid (CSF). It helps assess inflammation or infection in the brain and spinal cord.

Quick summary

["Neutrophils in CSF can signal serious conditions like meningitis or brain infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55790-0
Short code
Neuts Band CSF Manual
Synonyms
Neuts Band CSF Manual
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like severe headache, stiff neck, fever, confusion, or neurological issues. It’s often used to diagnose infections (e.g., bacterial meningitis) or other inflammatory conditions in the central nervous system.

What to Expect Before the Test

No special preparation is needed. A small amount of CSF is collected via a lumbar puncture (spinal tap) under sterile conditions. You may feel mild pressure or discomfort, but it’s usually brief.

How the Test Results Are Interpreted

Higher-than-normal neutrophil counts in CSF may indicate infection, inflammation, or other neurological disorders. Your doctor will compare results with your symptoms and other tests.

Common Conditions Affecting Results

Elevated neutrophils are often seen in bacterial meningitis, abscesses, or certain autoimmune diseases. Low or normal counts may suggest viral infections, non-infectious inflammation, or other conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Neutrophils in CSF are critical for diagnosing acute infections (e.g., bacterial meningitis) or identifying localized brain abscesses. They reflect the body’s immune response to pathogens or sterile inflammation, guiding urgent treatment decisions.

Short name

Neutrophil CSF Count

Frequently asked questions

What causes elevated neutrophils in CSF?
Elevated neutrophils in CSF are most commonly due to bacterial infections (e.g., meningitis), abscesses, or severe inflammatory reactions. Other rare causes may include certain autoimmune disorders or trauma.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on lab processing and your doctor’s urgency. Manual cell counts may take slightly longer than automated methods.
Can diet or medications affect this test?
No, this test is not influenced by diet or common medications. The CSF sample is collected fresh, and the manual count focuses on the cell composition in the fluid itself.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy