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Neutrophil Segment Count (Manual Differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the percentage of neutrophils, a type of white blood cell, in your blood using a manual differential count. Neutrophils help fight infections.

Quick summary

["Understanding your neutrophil count can help identify infection risks or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14107-7
Short code
Neuts Seg NFr CSF Manual
Synonyms
Neuts Seg NFr CSF Manual
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to evaluate your immune response, check for infections, or monitor conditions like chronic inflammation, autoimmune diseases, or certain cancers. It’s often used alongside other blood tests for a full picture of your health.

How the Test Works

A small blood sample is taken, and a trained lab technician manually examines the blood smear under a microscope. They count the different types of white blood cells, including neutrophils, to determine their proportion.

What to Expect Before the Test

No special preparation is needed for this test. You may have a slight bruise or soreness at the needle site, but it usually goes away quickly. If you’re on blood-thinning medication, let your doctor know before the test.

Possible Results and Interpretation

Results are typically expressed as a percentage of total white blood cells. A higher-than-normal neutrophil count may indicate infection, inflammation, or stress. A lower-than-normal count could suggest immune suppression or certain blood disorders. Your doctor will discuss these results with you in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Neutrophil Differential (Manual Count)

Frequently asked questions

What does a high neutrophil count mean?
A high neutrophil count often signals an active infection, such as bacterial infections, or conditions like chronic inflammation, stress, or certain cancers. It can also appear after physical exertion or during recovery from illness.
What does a low neutrophil count mean?
A low neutrophil count may indicate a weakened immune system, autoimmune diseases, certain medications (like chemotherapy), or severe infections. It’s important to discuss these findings with your healthcare provider to explore underlying causes.
How often should I get this test?
The frequency depends on your health condition and doctor’s recommendations. If you have a chronic illness or are undergoing treatment, your doctor may order this test regularly to monitor your immune response.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy