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Neutrophil Segment Count in Peripheral Blood (Manual Differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of neutrophils, a type of white blood cell, in your blood using a manual microscopic count. Neutrophils help fight infections and inflammation.

Quick summary

["Neutrophils are key defenders against bacterial infections and help manage inflammation in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71650-6
Short code
Neuts Seg NFr.DF Fld Manual
Synonyms
Neuts Seg NFr.DF Fld Manual
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
manual-count
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like frequent or recurring infections, unexplained fevers, or signs of inflammation. It could also be part of a routine blood check or to monitor conditions like leukemia, autoimmune diseases, or certain infections.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small needle inserted into your arm to draw a small amount of blood. The blood sample is then examined under a microscope by a trained technician to count neutrophils manually.

What the Test Results Mean

The result shows the absolute number of neutrophils per microliter of blood. While reference ranges vary by lab, a lower-than-normal count may indicate immune suppression, while a higher-than-normal count could suggest infection, inflammation, or other conditions.

Common Conditions Affecting Neutrophil Levels

Low neutrophil counts (neutropenia) may be linked to conditions like chemotherapy side effects, autoimmune diseases, or certain infections. High neutrophil counts (neutrophilia) can occur with bacterial infections, stress, or inflammatory processes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Neutrophil counts are critical for diagnosing and managing infections, autoimmune disorders, and blood disorders. Abnormal levels can signal underlying health issues that require further medical evaluation, such as infections, cancers, or immune system dysfunctions.

Short name

Neutrophil Count (Manual)

Frequently asked questions

What causes a low neutrophil count?
Low neutrophil counts can result from infections, certain medications (like chemotherapy), autoimmune diseases, or genetic conditions. Your doctor may also investigate if you have frequent infections or other symptoms like fatigue or weight loss.
What causes a high neutrophil count?
High neutrophil counts are often due to infections (especially bacterial), inflammation, or stress. They can also appear with certain cancers or blood disorders. If you notice unexplained swelling, fever, or persistent tiredness, discuss these findings with your healthcare provider.
How often should I get this test?
The frequency depends on your health condition. Routine blood tests may include this check, but your doctor will determine if follow-up testing is needed based on your symptoms and medical history.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy