Neisseria gonorrhoeae nucleic acid detection in cerebrospinal fluid (CSF) by nucleic acid amplification test (NAAT)

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like severe headache, stiff neck, fever, or confusion, which could signal meningitis. It’s also used in cases of suspected gonococcal infection in the nervous system, especially in individuals with risk factors for sexually transmitted infections (STIs).

What to Expect Before the Test

No special preparation is needed. A healthcare professional will collect a small amount of cerebrospinal fluid through a procedure called a lumbar puncture (spinal tap). This involves inserting a needle into your lower back, and you may feel pressure or mild discomfort during the procedure.

What the Test Results Mean

A positive result means gonococcal bacteria DNA is detected in your CSF, suggesting an infection that may require immediate treatment with antibiotics targeting gonorrhea. A negative result means no gonococcal DNA was found, but other causes of meningitis or neurological symptoms should still be evaluated.

Possible Side Effects or Risks

While rare, possible side effects of the lumbar puncture include mild headache, bruising, or soreness at the injection site. Infection at the needle site is also a very rare risk. If you experience severe pain, swelling, or signs of infection (like fever or redness), contact your healthcare provider immediately.