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Neisseria gonorrhoeae Nucleic Acid Test (CSF)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of gonorrhea bacteria in your cerebrospinal fluid (CSF), which may indicate meningitis caused by gonorrhea.

Quick summary

["A positive result helps guide treatment for suspected gonorrhea-related infections in the central nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42987-8
Short code
N gonorrhoea Ab Titr CSF
Synonyms
N gonorrhoea Ab Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like severe headache, stiff neck, fever, or confusion, combined with a history of gonorrhea exposure. It’s also used in patients with known gonorrhea infections who may have spread the infection to the brain or spinal cord.

What to Expect Before the Test

You’ll likely have a lumbar puncture (spinal tap) to collect CSF. This involves inserting a needle into your lower back to draw fluid. You may feel pressure or a slight ache, but it’s generally quick and done under local anesthesia.

What the Test Results Mean

A positive result means gonorrhea bacteria are detected in your CSF. A negative result means no bacteria were found, but it doesn’t rule out infection entirely—repeat testing may be needed if symptoms persist.

How the Test Works

The test uses nucleic acid amplification (likely polymerase chain reaction, or PCR) to identify genetic material from *Neisseria gonorrhoeae* in the CSF sample. This method is highly sensitive and specific for detecting the bacteria.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Gonorrhea CSF Test

Frequently asked questions

What does a positive result mean?
A positive result strongly suggests gonorrhea meningitis, which requires immediate antibiotic treatment. Untreated gonorrhea can lead to serious complications, including permanent brain damage or death.
Could a negative result mean I still have an infection?
Yes, false negatives can occur, especially if the infection is early or not severe. If symptoms persist, your provider may repeat the test or order additional tests, such as blood cultures or imaging studies.
How soon will I get my results?
Results are typically available within 24 to 48 hours, depending on lab processing times. Your healthcare provider will discuss the results with you and guide next steps, such as treatment or further testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy