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Neisseria gonorrhoeae Antigen Detection in Cerebrospinal Fluid by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of *Neisseria gonorrhoeae* bacteria in your cerebrospinal fluid (CSF), which may indicate meningitis caused by gonorrhea.

Quick summary

["Determines if gonococcal infection could be affecting your brain or spinal cord fluid."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27021-5
Short code
N gonorrhoea Ab Titr CSF CF
Synonyms
N gonorrhoea Ab Titr CSF CF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like severe headache, stiff neck, fever, or confusion, especially if you’ve been exposed to gonorrhea or have a known infection. It’s also used in certain cases of unexplained neurological symptoms or after a head injury.

What to Expect Before the Test

You’ll likely have a lumbar puncture (spinal tap) to collect the CSF. The procedure is quick but may cause temporary discomfort. No special preparation is needed, but inform your provider about any medications you’re taking.

What the Test Results Mean

A positive result means the test detected gonococcal bacteria in your CSF, which could indicate gonococcal meningitis. A negative result suggests no bacteria were found, but other causes of meningitis (like viral or bacterial infections) could still be present.

Possible Causes and Alternatives

If your test is negative but you still have symptoms, other infections (e.g., viral meningitis, tuberculosis, or other bacterial causes) may be investigated. Follow-up tests or cultures may be needed to identify the exact cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Gonococcal Antigen CSF Test

Frequently asked questions

What does gonococcal meningitis mean for my health?
Gonococcal meningitis is a serious infection that can lead to severe complications like brain swelling, seizures, or long-term neurological damage if untreated. Early treatment with antibiotics is critical to prevent these risks.
How soon will I know my results?
Results are typically available within 24–48 hours, but timing may vary. Your healthcare provider will discuss the findings with you during a follow-up visit.
Can I prevent gonococcal meningitis?
Yes! Practice safe sex (e.g., condoms), avoid sharing needles, and get vaccinated against meningococcal disease if recommended by your provider. If you suspect exposure, seek medical attention promptly.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy