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C-reactive protein (CRP) – Serum/Plasma Substance Concentration (High-Sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by your liver in response to inflammation, helping detect low-grade inflammation that may not be obvious otherwise.

Quick summary

["High sensitivity CRP helps track subtle inflammation, often used alongside other tests for early disease monitoring."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96489-0
Short code
NIF-L IgG CSF Ql CBA IFA
Synonyms
NIF-L IgG CSF Ql CBA IFA
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a high-sensitivity CRP test to assess for signs of inflammation, monitor chronic conditions like arthritis or cardiovascular risk, or evaluate responses to treatments. It’s particularly useful when other tests show mild or undetectable inflammation levels.

What to Expect Before the Test

No special preparation is needed. You may have blood drawn from a vein in your arm. If you’re on blood thinners, inform your provider beforehand to avoid delays or complications.

What the Results Mean

Results are not typically provided in absolute numbers but are compared to a reference range for your age and health status. Elevated levels may indicate inflammation, infection, or certain autoimmune conditions, while very low levels may suggest no active inflammation.

Common Conditions Monitored

High-sensitivity CRP is often used to monitor conditions like rheumatoid arthritis, cardiovascular disease risk, or inflammatory bowel disease. It can also help guide decisions about starting or adjusting medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does a high or low CRP level mean?
A high CRP level suggests inflammation is present, which could be due to infection, injury, or an autoimmune condition. A low level typically means there is little to no active inflammation, but this can vary based on your overall health and medical history.
Can diet or lifestyle affect CRP levels?
Yes, diet, exercise, and stress levels can influence CRP. Eating a balanced diet, managing weight, and reducing stress may help lower inflammation over time. Always discuss lifestyle changes with your healthcare provider before making significant adjustments.
Is CRP the same as a regular CRP test?
No. High-sensitivity CRP (hs-CRP) is more sensitive and detects smaller amounts of inflammation than standard CRP tests, making it useful for monitoring subtle changes in chronic conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy