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Fecal Immunochemical Test for Occult Blood (FIT) – High Sensitivity (DNA-based)

Published: August 9, 2026Updated: August 16, 2026

This test detects hidden (occult) blood in your stool using a DNA-based method to help screen for colorectal cancer or other gastrointestinal bleeding.

Quick summary

A simple stool test to check for hidden blood, which may signal potential health concerns like bleeding in the digestive tract.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92901-8
Short code
NIP fet aneu microdel pnl Plas.cfDNA Seq
Synonyms
NIP fet aneu microdel pnl Plas.cfDNA Seq
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
sequencing
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

How the Test Works

The test analyzes stool samples for DNA fragments associated with human blood. Unlike traditional chemical tests, this method is highly sensitive and specific, reducing false positives while improving accuracy for early detection.

What to Expect Before the Test

No special preparation is needed. Simply collect a small sample of stool in a provided container. If you’re using a kit, follow the instructions carefully to ensure accurate results. Avoid using laxatives or certain medications that could interfere with the test.

Common Uses and Benefits

This test is primarily used as a screening tool for colorectal cancer or to detect gastrointestinal bleeding. It’s often recommended for adults at average risk of colorectal cancer, though your doctor may suggest it based on your medical history or symptoms.

What the Results Mean

A positive result indicates the presence of occult blood, which may warrant further evaluation (such as a colonoscopy) to investigate potential causes like polyps, ulcers, or cancer. A negative result means no detectable blood was found in this sample, but it doesn’t rule out bleeding entirely.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

High-sensitivity FIT

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if you’re at average risk for colorectal cancer, have symptoms like unexplained weight loss, changes in bowel habits, or persistent abdominal discomfort. It’s also sometimes used as part of a routine screening program, especially for older adults.
What if I have a positive result?
A positive result means you’ll likely need additional testing, such as a colonoscopy, to find the source of the blood. This could help identify issues like polyps, inflammation, or cancer. Follow-up care is guided by your healthcare provider’s recommendations.
Can I take this test at home?
Yes, many providers offer at-home FIT kits. If you’re using one, follow the instructions carefully to ensure proper sample collection. If you’re unsure or have concerns, always consult your doctor before proceeding.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy