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Serum or Plasma Creatinine Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function by evaluating how well your kidneys remove waste from your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45183-1
Short code
N men Islt Aggl
Synonyms
N men Islt Aggl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
aggl
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle breakdown and is naturally filtered out by your kidneys. If your kidneys aren’t working properly, creatinine levels can build up in your blood. This test is a key part of checking kidney health, especially if you have symptoms like swelling, fatigue, or changes in urine output.

What to Expect Before the Test

You may be asked to fast for a few hours before the test, but this depends on your doctor’s instructions. A simple blood draw is all that’s needed—just a small needle prick at your vein. No special preparation is usually required beyond showing up rested and hydrated.

What the Results Mean

Higher-than-normal levels may signal kidney problems, while lower levels could indicate dehydration or muscle loss. Your doctor will compare your results to your health history and other tests to interpret them accurately.

Common Causes of Abnormal Results

Kidney disease, dehydration, or conditions like heart failure or diabetes can affect creatinine levels. Other factors, such as recent exercise or certain medications, might also influence the results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a critical marker for kidney function. Elevated levels often indicate impaired kidney filtration, which can lead to long-term health risks like fluid buildup, electrolyte imbalances, or even kidney failure if untreated. Low levels may suggest dehydration or reduced muscle mass, but further evaluation is needed to rule out other causes.

Short name

Creatinine

Frequently asked questions

Why might my creatinine test be done?
Your doctor may order this test to check for kidney problems, monitor chronic conditions like diabetes or heart disease, or evaluate symptoms like swelling, nausea, or changes in urine. It’s also part of routine health screenings for older adults or those with risk factors.
Could food or medications affect my test results?
Some medications (like NSAIDs or certain diuretics) or foods high in potassium (e.g., bananas) might influence creatinine indirectly, but the test itself measures creatinine in your blood, not dietary intake. Always follow your doctor’s specific instructions for timing.
What if my results are out of the normal range?
If your results are abnormal, your doctor will discuss them with you and may recommend further tests, like additional bloodwork or imaging, to find the cause. They’ll also consider your overall health and symptoms before making a diagnosis.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy