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Serological Grouping by Antigen Detection (e.g., Blood Grouping System)

Published: August 9, 2026Updated: August 17, 2026

This test helps determine your blood type by identifying specific antigens on your red blood cells, which is essential for safe blood transfusions and pregnancy care.

Quick summary

["Your blood type affects compatibility for transfusions and pregnancy outcomes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
70172-2
Short code
N men serogroup Spec
Synonyms
N men serogroup Spec
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters in Everyday Life

Blood type is determined by the presence or absence of certain antigens (proteins) on your red blood cells. The most common blood groups are A, B, AB, and O, with additional subgroups (e.g., Rh positive/negative). This test checks for these antigens to ensure compatibility during medical procedures like transfusions or surgeries.

How the Test Works

A small blood sample is taken from your arm. The sample is then tested using specialized reagents that react with your red blood cells to identify specific antigens. The results are typically reported as A, B, AB, O, or Rh positive/negative.

When You Might Need This Test

You may need this test before surgeries, during pregnancy (especially in the first trimester), or if you require a blood transfusion. Doctors also use it to screen blood donations for compatibility.

What to Expect During the Test

The process is quick and painless. A healthcare provider will insert a small needle into your vein to draw a few drops of blood. You may feel a slight pinch, but most people find it minimal. The test itself takes only a few minutes, and the blood sample is then analyzed in a lab.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Blood Type Screening

Frequently asked questions

What does a positive or negative result mean for my blood type?
A positive result for a specific antigen (e.g., A antigen) means it is present on your red blood cells. A negative result means it is not present. For example, if your test shows A+, you have the A antigen and Rh factor. This information is used to determine compatibility for transfusions or surgeries.
How often should I get this test?
Blood type screening is typically done once as part of routine medical check-ups unless you have specific medical needs (like pregnancy or planned transfusions). If you are pregnant, your doctor may recommend retesting in the first trimester.
Can my blood type change over time?
Blood type is generally stable and does not change throughout your life. However, rare cases of autoimmune conditions or certain blood disorders may temporarily alter antigen presence, but this is uncommon.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy