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Cerebrospinal Fluid (CSF) Protein by Nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein levels in your cerebrospinal fluid, which helps assess conditions affecting the brain and spinal cord.

Quick summary

["Protein levels in CSF can signal inflammation, bleeding, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6493-1
Short code
N men sg A Ag CSF Ql IA
Synonyms
N men sg A Ag CSF Ql IA
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is Cerebrospinal Fluid (CSF)?

Cerebrospinal fluid (CSF) is a clear fluid that surrounds and protects your brain and spinal cord. It acts as a cushion and helps remove waste products. When protein levels in CSF are measured, it can help identify problems like infections, tumors, or autoimmune diseases.

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues. It’s also used to diagnose conditions such as meningitis, multiple sclerosis, or other spinal cord disorders.

How Is the Test Performed?

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed in a lab to measure protein content using nephelometry, a technique that detects particles in the fluid.

What Are Common Findings?

Elevated protein levels in CSF can indicate inflammation, infection, or blood leakage into the spinal fluid. Lower-than-normal levels may suggest certain genetic or metabolic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated CSF Protein Levels

Short name

CSF Protein

Frequently asked questions

How often will I need this test?
The frequency depends on your symptoms and diagnosis. Your doctor may recommend retesting if symptoms persist or worsen.
What do my results mean?
Results are interpreted by your healthcare provider based on your medical history and symptoms. They may compare your levels to others with similar conditions or use them alongside other tests.
Can I eat or drink before the test?
No special preparation is needed, but avoid caffeine or alcohol before the lumbar puncture if instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy