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Serum or plasma concentration of total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps your body stay healthy and function properly.

Quick summary

["Total protein helps assess overall health and detect potential issues like kidney problems or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42369-9
Short code
N men sg A Ag Islt Ql Aggl
Synonyms
N men sg A Ag Islt Ql Aggl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
aggl
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help monitor treatments for certain illnesses.

What Does the Result Mean?

Higher-than-normal results might suggest conditions like liver disease or dehydration, while lower-than-normal results could indicate malnutrition, kidney disease, or severe burns.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma for testing. This test does not require fasting.

Common Conditions Monitored

Your provider may use this test to monitor conditions such as chronic kidney disease, liver disease, or to evaluate nutritional status over time.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels can provide important clues about your body’s ability to retain fluids, filter waste, and maintain protein balance. Abnormal results often point to underlying health issues that need further investigation, such as protein-losing conditions or organ dysfunction.

Short name

Total Protein

Frequently asked questions

What causes total protein levels to be too high?
High total protein levels may be due to conditions like liver disease, dehydration, or certain types of cancer. Chronic inflammation or exposure to toxins can also contribute.
What causes total protein levels to be too low?
Low total protein levels can result from malnutrition, kidney disease, severe burns, or conditions that affect protein absorption in the gut. Chronic liver disease or certain medications may also play a role.
Do I need to prepare for this test?
No special preparation is needed for this blood test. However, always inform your healthcare provider about any medications or supplements you’re taking, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy