Skip to content

Serum or Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

A creatinine test helps check kidney function by measuring waste removal efficiency.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31910-3
Short code
N men sg A+C+W135+Y Ag Spec Ql
Synonyms
N men sg A+C+W135+Y Ag Spec Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle breakdown and is filtered out of your blood by your kidneys. High levels may indicate poor kidney function, while low levels could suggest overhydration or muscle loss. This test is often used alongside other kidney function tests to diagnose conditions like chronic kidney disease.

What to Expect Before the Test

No special preparation is needed unless instructed by your healthcare provider. You may have a small needle inserted into your arm to draw blood. If a urine sample is involved (e.g., a 24-hour collection), follow specific instructions to collect the sample accurately.

What the Results Mean

Results are typically reported as a concentration in milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). While reference ranges vary by lab, higher-than-normal levels may signal kidney issues, while very low levels may warrant further investigation.

Common Conditions Monitored

This test is commonly used to monitor kidney disease, dehydration, muscle disorders, and to evaluate the effectiveness of treatments for conditions like heart failure or certain medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a key indicator of kidney function because they reflect how well your kidneys remove waste products from your blood. Elevated levels can signal early kidney damage, while persistently low levels may require additional evaluation to rule out conditions like severe dehydration, muscle wasting, or certain metabolic disorders. It’s often used in conjunction with other tests, such as blood urea nitrogen (BUN), to assess kidney health comprehensively.

Short name

Creatinine Level

Frequently asked questions

How often should I get this test?
The frequency depends on your health condition. If you have kidney disease, diabetes, or heart problems, your doctor may recommend regular testing. Otherwise, this test is often part of routine check-ups or when symptoms like fatigue, swelling, or changes in urine appear.
What can affect my creatinine levels?
Several factors can influence creatinine levels, including muscle mass (higher muscle mass can lead to higher levels), dehydration or overhydration, certain medications, and kidney-related conditions. If you’ve had recent changes in activity, diet, or medication, let your doctor know to ensure accurate interpretation.
Do I need to fast before this test?
No fasting is required for this test, as it measures waste products in your blood or plasma. However, if you’re having a 24-hour urine collection for creatinine clearance, follow specific instructions provided by your healthcare team.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy