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Serum or plasma mass concentration of glycine

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of glycine, an amino acid found in your blood. Glycine plays a role in protein synthesis, metabolism, and helps maintain normal fluid balance.

Quick summary

["Glycine levels can help diagnose or monitor certain metabolic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31526-7
Short code
N men sg A IgG Ser-aCnc
Synonyms
N men sg A IgG Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Glycine?

Glycine is one of the simplest amino acids and serves as a building block for proteins. It also helps regulate blood pressure, supports nerve function, and aids in the production of glucose. Your body naturally produces glycine, but certain conditions or medications may affect its levels in your blood.

Why Might You Need This Test?

Your healthcare provider may order a glycine test if you have symptoms like fatigue, muscle weakness, or unusual fluid retention. It may also be used to evaluate metabolic disorders, kidney function, or conditions involving abnormal protein metabolism.

How Is the Test Done?

A blood sample is taken from a vein, usually in your arm. The sample is then sent to a lab for analysis to measure glycine concentration. The test typically requires fasting, but this may vary by provider.

What Do Results Mean?

Results are compared to standard reference ranges, though exact values can vary by lab. Abnormal results may indicate metabolic issues, kidney problems, or other underlying health conditions that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Glycine Levels and Health

Short name

Glycine Level

Frequently asked questions

How often do glycine levels change in healthy individuals?
Glycine levels can fluctuate slightly due to diet, hydration status, or certain medications. However, significant or persistent deviations from normal may warrant further medical investigation, especially if symptoms like fatigue or muscle issues are present.
Can diet affect glycine test results?
Yes, dietary intake of glycine-rich foods (like gelatin, collagen, or certain supplements) may temporarily influence results. Fasting guidelines should be followed as directed by your healthcare provider to ensure accurate testing.
What conditions might lead to abnormal glycine levels?
Abnormal glycine levels may be linked to metabolic disorders (e.g., glycine cleavage deficiency), kidney disease, liver dysfunction, or certain genetic conditions. Always discuss your results with your doctor to determine next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy