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Bilirubin, Total (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood. Bilirubin is a yellow pigment produced when red blood cells break down, and it helps the liver process waste products.

Quick summary

["Your liver plays a key role in breaking down bilirubin, and high levels may signal potential liver or bile duct issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31915-2
Short code
N men sg B+E coli K1 Ag Spec Ql
Synonyms
N men sg B+E coli K1 Ag Spec Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order this test to check for liver disease, bile duct blockages, or other conditions affecting how your body processes bilirubin. It can also help diagnose jaundice (yellowing of the skin and eyes) or monitor conditions like hemolytic anemia or hepatitis.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw blood. Tell your healthcare provider if you’re on blood thinners or have a history of bleeding issues.

What the Results Mean

Results are typically compared to a reference range, but exact values depend on lab standards. High levels may indicate liver problems, gallbladder issues, or red blood cell breakdown. Low levels are less common but could signal liver disease or certain blood disorders.

Common Conditions Linked to Bilirubin Levels

Elevated bilirubin is often linked to liver diseases (like hepatitis or cirrhosis), bile duct obstructions (such as gallstones), or conditions that cause red blood cells to break down faster (like hemolytic anemia). Jaundice, a yellowing of the skin or eyes, is a visible sign of high bilirubin.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Serum Bilirubin

Frequently asked questions

Could my bilirubin levels be affected by what I eat or drink?
Dietary factors like fatty foods or alcohol may temporarily influence liver function, but they don’t directly affect bilirubin levels. Stick to your usual diet unless advised otherwise by your doctor.
What should I do if my bilirubin is high?
If your results are elevated, your doctor may recommend further tests (like liver function tests or imaging) to find the cause. Follow their instructions for treatment or lifestyle changes if needed.
Is this test painful?
The blood draw itself is mild discomfort, but most people tolerate it well. You may feel a slight pinch or sting, but it’s over quickly. Rest and stay hydrated afterward to help your body process bilirubin normally.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy