Skip to content

Cerebrospinal fluid (CSF) protein concentration (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your cerebrospinal fluid, which surrounds your brain and spinal cord. Protein levels can help identify issues like inflammation, infections, or blood leakage into the CSF.

Quick summary

["Protein in CSF may signal conditions affecting your nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31916-0
Short code
N men sg C Ag CSF Ql
Synonyms
N men sg C Ag CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like headaches, neck stiffness, confusion, or neurological problems. It can also help diagnose conditions such as meningitis, multiple sclerosis, or brain tumors.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your back to collect a small amount of CSF. This is usually done in a hospital or clinic setting.

What the Results Mean

Normal protein levels in CSF are generally lower than in blood. High levels may indicate inflammation, infection, or bleeding into the brain. Low levels might suggest certain genetic disorders or other rare conditions.

Common Conditions Affecting Results

Elevated protein levels can be seen in conditions like Guillain-Barré syndrome, multiple sclerosis, or infections such as bacterial or viral meningitis. Blood in the CSF (from a head injury or bleeding disorder) can also raise protein levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing and monitoring neurological disorders. It helps doctors assess the health of your central nervous system and guide treatment decisions.

Short name

CSF Protein Level

Frequently asked questions

Will I feel pain during the test?
You may feel a slight pinch or discomfort when the needle is inserted, but it usually doesn’t cause significant pain. Afterward, you might have mild soreness or a small bruise.
How long will I need to rest after the test?
You’ll typically need to lie flat for a few hours to prevent any leakage of CSF. Your doctor will give specific instructions based on your situation.
Can I drink or eat before this test?
No special restrictions apply, but follow your doctor’s advice if you have any specific instructions for your procedure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy