Cerebrospinal fluid (CSF) protein concentration (mass concentration)
This test measures the total protein found in your cerebrospinal fluid, which surrounds your brain and spinal cord. Protein levels can help diagnose or monitor conditions affecting the central nervous system.
["Protein in CSF may indicate inflammation, infection, or other neurological issues."]
Key facts at a glance
- LOINC
- 17329-4
- Short code
- N men sg C Ag CSF Ql IF
- Synonyms
- N men sg C Ag CSF Ql IF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- if
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, confusion, or signs of nerve or brain problems. It can also be used to check for conditions such as multiple sclerosis, meningitis, or brain tumors.
What to Expect Before the Test
No special preparation is needed. You may be asked to lie down on an examination table, and a small needle will be inserted into your back to collect a small amount of CSF. This is usually done in a hospital or clinic setting.
What Happens During the Test
A healthcare professional will insert a needle into your lower back to collect CSF. You may feel a slight pinch, but the procedure is generally quick and painless. The collected fluid will be sent to the lab for testing.
What the Results Mean
Protein levels in CSF can vary based on health conditions. Elevated levels might suggest inflammation, infection, or other neurological disorders. Your doctor will interpret the results in the context of your symptoms and medical history.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Elevated CSF protein levels can signal conditions like meningitis, multiple sclerosis, or tumors affecting the central nervous system. Low levels may indicate normal function or certain neurological disorders. Always discuss results with your healthcare provider for personalized insights.
Short name
CSF Protein Level
Frequently asked questions
How often can I expect to get this test?
What are common symptoms that might lead to this test?
Will I feel any pain or discomfort during the procedure?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy