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C-reactive protein (CRP) by nephelometry (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body.

Quick summary

["CRP helps doctors assess inflammation, often used to monitor conditions like infections, autoimmune diseases, or after surgery."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
19022-3
Short code
N men sg C+W135 Ag CSF Ql
Synonyms
N men sg C+W135 Ag CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for signs of inflammation, monitor chronic conditions like rheumatoid arthritis or lupus, evaluate infections, or assess risk for heart disease. It can also help determine how well treatment is working for certain conditions.

What Does a High or Low CRP Level Mean?

Elevated CRP levels often indicate inflammation or infection. Very high levels may suggest severe infections, infections in internal organs, or conditions like sepsis. Low levels usually mean there is little to no inflammation, but this can vary depending on your overall health and specific medical context.

How Is This Test Performed?

A blood sample is taken from a vein in your arm. The blood is then sent to a lab where it is analyzed using nephelometry, a method that measures how much light is scattered by the CRP protein in your serum or plasma.

What Are Common Conditions Monitored With CRP?

CRP is commonly used to monitor conditions such as inflammatory diseases (e.g., rheumatoid arthritis, lupus), infections (e.g., pneumonia, urinary tract infections), heart disease risk, and to evaluate responses to treatments like steroids or biologic medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: CRP is a marker of systemic inflammation. While it doesn’t specifically identify the cause of inflammation, it provides a general indication of whether inflammation is present. High CRP levels can prompt further testing or adjustments in treatment plans, especially in chronic inflammatory diseases or cardiovascular risk assessments.

Short name

CRP (Nephelometry)

Frequently asked questions

What does a CRP test measure?
A CRP test measures the amount of C-reactive protein in your blood. This protein is produced by your liver and rises in response to inflammation or infection.
How often should I get a CRP test?
The frequency depends on your medical condition and healthcare provider’s recommendations. Some people get CRP tests regularly to monitor chronic conditions, while others may only need it if symptoms or other tests suggest inflammation is present.
Can CRP levels change with diet or lifestyle?
Yes, lifestyle factors like diet, exercise, and smoking can influence CRP levels. Reducing inflammation through healthy eating, regular physical activity, and avoiding smoking may help lower CRP levels over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy