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C-reactive protein (CRP) by nephelometry (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein called C-reactive protein (CRP), which your body produces in response to inflammation. CRP helps doctors assess whether you have an inflammatory condition, infection, or other health issues that cause swelling in your body.

Quick summary

["CRP helps track inflammation, guiding treatment decisions and monitoring conditions like infections or autoimmune diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17325-2
Short code
N men sg C+W135 Ag Ur Ql
Synonyms
N men sg C+W135 Ag Ur Ql
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why CRP Matters in Your Health

CRP is often used as a simple blood test to detect inflammation, which can signal underlying health problems. High levels may indicate conditions such as infections, autoimmune diseases (like rheumatoid arthritis), or other inflammatory processes. Doctors may order this test to monitor chronic conditions or check for signs of new health concerns.

How the Test Works

Your blood sample is analyzed using a nephelometric method, which measures how much CRP is present in your serum or plasma. This test is highly sensitive and can detect even small amounts of CRP, making it useful for early detection of inflammation.

What to Expect Before the Test

No special preparation is usually needed for this test. You may be asked to fast for 8–12 hours before the blood draw if your doctor specifies it, but this is not always required. Avoiding strenuous activity or certain medications (like nonsteroidal anti-inflammatory drugs) may be advised if your doctor recommends it.

What the Results Mean

Results are reported in milligrams per liter (mg/L) or micrograms per milliliter (µg/mL). While reference ranges vary by lab, very high levels (above 10 mg/L) often signal severe inflammation or infection, while moderate levels (3–10 mg/L) may indicate mild inflammation. Your doctor will interpret results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CRP (High-Sensitivity)

Frequently asked questions

What does CRP measure?
CRP measures the level of a protein produced by your liver in response to inflammation. It’s a marker that helps doctors identify whether inflammation is present in your body, which can guide treatment for conditions like infections, autoimmune diseases, or other inflammatory disorders.
Can CRP levels change with diet or exercise?
Yes, lifestyle factors like diet, exercise, and stress can influence CRP levels. Certain foods (such as omega-3 fatty acids, fruits, and vegetables) may help reduce inflammation, while poor diet, smoking, or obesity can increase CRP. However, CRP is not the only factor doctors consider when evaluating inflammation.
How often should I get a CRP test?
Your doctor will determine how often you need a CRP test based on your medical history, symptoms, and treatment plan. Some people get it annually or more frequently if they have chronic conditions like heart disease or arthritis. Follow your healthcare provider’s recommendations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy