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Cerebrospinal Fluid Protein by Turbidimetry (Total Protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Protein levels can help diagnose conditions affecting the central nervous system.

Quick summary

["Protein in CSF may signal inflammation, infection, or structural issues in the brain or spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109776-5
Short code
N men sg W135 Ag Msmt CSF
Synonyms
N men sg W135 Ag Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues. It can also be part of a broader evaluation for conditions such as multiple sclerosis, meningitis, or brain tumors.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your back to collect a small sample of CSF, which is then sent to the lab for testing.

What the Results Mean

Higher-than-normal protein levels in CSF can indicate inflammation, infection, or other neurological disorders. Lower-than-normal levels may suggest conditions like Guillain-Barré syndrome or certain genetic disorders.

Common Conditions Affecting Results

Elevated protein levels are often seen in conditions such as multiple sclerosis, encephalitis, or subarachnoid hemorrhage. Low protein levels may be associated with rare metabolic or genetic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test helps doctors diagnose and monitor conditions that affect the brain and spinal cord by providing insight into the protein content in cerebrospinal fluid, which can reflect underlying inflammation, infection, or structural damage.

Short name

CSF Protein Level

Frequently asked questions

What causes abnormal protein levels in CSF?
Abnormal protein levels in CSF can result from conditions like infections (e.g., meningitis), autoimmune diseases (e.g., multiple sclerosis), or structural issues (e.g., tumors). Your doctor will consider your symptoms and other test results to determine the cause.
How often should I get this test?
The frequency depends on your symptoms and medical needs. Your doctor may recommend retesting if symptoms persist or if they suspect a worsening or changing condition.
Can diet or lifestyle affect this test?
Diet or lifestyle factors typically do not directly influence CSF protein levels, as the fluid is collected directly from the central nervous system. However, avoid strenuous activity or caffeine before the procedure to ensure accuracy.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy