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C-reactive protein (CRP) by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein in your blood, a protein produced by your liver in response to inflammation or infection.

Quick summary

["CRP helps doctors track inflammation and identify possible infections or conditions causing swelling in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42373-1
Short code
N men sg X Ag Islt Ql Aggl
Synonyms
N men sg X Ag Islt Ql Aggl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
aggl
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why CRP Matters in Your Health

CRP is often used to monitor conditions like arthritis, heart disease, or infections. High levels may signal inflammation, which can be linked to conditions like autoimmune diseases or chronic illnesses. It’s also sometimes checked after surgery or injury to see how your body is healing.

How the Test Works

Your blood sample is analyzed using a method called nephelometry, which detects the amount of CRP in your plasma. This test doesn’t require fasting and is typically done as part of a routine checkup or to investigate symptoms like fever, fatigue, or joint pain.

What to Expect Before the Test

No special preparation is needed for this test. You can eat, drink, or take medications as usual. The blood is drawn from a vein, usually in your arm, and the process is quick and usually painless.

Possible Results and Next Steps

Results may be interpreted by your healthcare provider based on your overall health and symptoms. Very high CRP levels might prompt further testing, such as blood cultures or imaging, to find the cause of inflammation. Very low levels might raise questions about underlying conditions that need investigation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CRP

Frequently asked questions

What does a high CRP level mean?
A high CRP level often indicates inflammation in your body, which can be caused by infections (like pneumonia or urinary tract infections), autoimmune diseases (like rheumatoid arthritis), or other conditions causing chronic inflammation. It’s not specific to any one disease but helps guide further testing or treatment decisions.
What does a low CRP level mean?
A low CRP level usually means there isn’t much inflammation detected in your blood at the time of testing. However, it doesn’t rule out conditions that might cause inflammation, so your doctor may still recommend other tests or follow-ups if you have symptoms.
Can CRP levels change over time?
Yes, CRP levels can change depending on your health status, recent infections, medications, or other treatments. If your CRP level is elevated, your doctor may retest it later to see how your body responds to treatment or changes in your condition.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy