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Serum or plasma concentration of total bilirubin

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin, a yellow pigment produced when red blood cells break down. It helps assess liver function and detect conditions like jaundice or bile duct blockages.

Quick summary

["Total bilirubin levels can signal liver or bile flow issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6505-2
Short code
N men sg Y Ag CSF Ql LA
Synonyms
N men sg Y Ag CSF Ql LA
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
la
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why is this test done?

Your doctor may order a total bilirubin test to check for liver problems, such as hepatitis, cirrhosis, or gallbladder issues. It can also help diagnose conditions like hemolytic anemia, where red blood cells break down faster than usual. Sometimes, it’s used to monitor treatment progress or check for bile duct blockages.

What does a result mean?

Bilirubin is usually processed by the liver and excreted in urine or bile. High levels may indicate liver disease, bile duct problems, or red blood cell disorders. Low levels might suggest liver disease or certain genetic conditions. Your doctor will interpret results in the context of your overall health and symptoms.

How is the test performed?

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab, where bilirubin levels are measured using a specialized test that detects its presence in the blood.

What can affect results?

Several factors can influence bilirubin levels, including diet (e.g., high intake of certain foods or supplements), medications (like certain antibiotics or painkillers), dehydration, or recent blood transfusions. Illnesses like infections or severe stress can also temporarily raise levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated total bilirubin is often a red flag for liver or bile duct problems. It can help identify conditions like jaundice, liver inflammation (hepatitis), bile duct obstructions, or hemolytic anemia. Low levels may suggest liver disease or certain metabolic disorders. Your doctor will use these results alongside other tests and symptoms to guide diagnosis and treatment.

Short name

Total bilirubin

Frequently asked questions

How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time. Your doctor will contact you once they have the results.
Can I eat or drink before the test?
You can usually eat and drink normally before the test unless your doctor advises otherwise. Some labs may ask for fasting, but bilirubin tests do not require fasting.
Is there anything I should avoid before the test?
Avoid taking certain medications that might affect bilirubin levels, such as some antibiotics or pain relievers, unless your doctor approves. Also, inform your doctor about any recent illnesses or injuries that might impact results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy