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Protein Electrophoresis, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, including albumin and globulins, which help your body function properly.

Quick summary

["It helps identify protein imbalances that may signal conditions like kidney disease or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
86198-9
Short code
N men sg Y synF Ct Spec Qn NAA+probe
Synonyms
N men sg Y synF Ct Spec Qn NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to diagnose or monitor conditions affecting protein levels in the blood, such as kidney disease, liver disease, multiple myeloma, or certain autoimmune disorders. It can also help evaluate nutritional status or response to treatment.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, inform your doctor beforehand.

How the Test Works

Blood is collected and separated into components. The proteins are then separated using an electric field, creating bands that correspond to different protein types. These bands are analyzed to determine their relative amounts.

Possible Results and Interpretation

Results show the distribution of proteins (e.g., albumin, alpha-globulins, beta-globulins, gamma-globulins). Abnormal patterns may indicate conditions like hypoalbuminemia, dysproteinemias, or immune system issues.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Protein Electrophoresis

Frequently asked questions

What does an abnormal protein electrophoresis mean?
An abnormal result may suggest conditions like kidney or liver disease, certain cancers (e.g., multiple myeloma), or immune system disorders. Your doctor will discuss findings with you during your follow-up visit.
How often should I get this test?
Frequency depends on your health condition and doctor’s recommendations. Some patients need it yearly or more often if they have chronic diseases like kidney or liver problems.
Can diet affect protein electrophoresis results?
Dietary changes may influence protein levels, especially if you have kidney or liver issues. Always follow your doctor’s advice regarding diet and test timing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy