Genetic Mutation Analysis for NOD2 Gene (Blood)
This test checks for mutations in the NOD2 gene, which may be linked to certain inflammatory bowel disease (IBD) conditions, including Crohn’s disease.
["This test helps assess genetic risk for IBD-related conditions."]
Key facts at a glance
- LOINC
- 41115-7
- Short code
- NOD2 gene Mut Anl Bld/T
- Synonyms
- NOD2 gene Mut Anl Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, or if you have symptoms that suggest a genetic component to your condition. It may also be used in research or specialized genetic counseling settings.
What to Expect Before the Test
You will provide a blood sample, typically drawn from a vein in your arm. The process is quick and usually painless. No special preparation is needed, but inform your provider about any medications you’re taking.
What the Test Measures
The test analyzes DNA from your blood to identify specific changes (mutations) in the NOD2 gene. These mutations are associated with an increased risk of developing Crohn’s disease or other IBD-related conditions.
What the Results Mean
Results may show whether you carry certain NOD2 gene mutations. If mutations are found, they may help explain your risk for IBD or guide treatment decisions in consultation with a healthcare provider.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
NOD2 Gene Mutation Test
Frequently asked questions
Genetic mutations in the NOD2 gene are linked to an increased likelihood of developing Crohn’s disease, particularly in certain ethnic groups. Identifying these mutations can support diagnosis, inform genetic counseling, or help tailor personalized treatment plans.
A positive result indicates the presence of specific NOD2 gene mutations that may increase your risk of developing Crohn’s disease or related IBD conditions. This finding should be discussed with your healthcare provider to understand implications for your care.
No, this test is not a diagnostic tool for IBD. It helps assess genetic risk and may support broader diagnostic evaluations, including clinical symptoms, medical history, and other tests.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy