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Colorectal Cancer DNA Screening in Stool (Multiplex Tumor DNA Analysis)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from potential colorectal cancer cells in your stool, helping detect early signs of colorectal cancer or precancerous changes.

Quick summary

["A non-invasive way to screen for colorectal cancer risk using DNA from stool samples."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77353-1
Short code
Noninv colon ca DNA+occ bld scrn Stl-Imp
Synonyms
Noninv colon ca DNA+occ bld scrn Stl-Imp
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

This test measures specific substances in your body to help your healthcare provider learn more about your overall health. It can show how well certain organs are working and whether there are signs of infection, inflammation, or other conditions that may need further evaluation or treatment.

The test analyzes DNA fragments from cells in your stool, including those that may indicate colorectal cancer or precancerous polyps. It looks for genetic markers (mutations or abnormalities) that are more common in cancerous or precancerous cells.

This test is performed by collecting a small sample from your body, most often a blood or urine sample, at a laboratory, clinic, or hospital. A trained staff member will guide you through the process, and the sample is then sent to a lab where specialists analyze it and report the results to your provider.

You’ll collect a sample of stool using a provided kit, which is then sent to a lab for analysis. The test is typically done as part of a screening process, often over a 24-hour period or as a single sample collection.

Your healthcare provider may order this test as part of a routine checkup, to help diagnose the cause of symptoms you are experiencing, to monitor a condition you already have, or to see how well a treatment is working over time. It provides valuable information that helps guide decisions about your care.

Your healthcare provider may recommend this test if you’re at higher risk for colorectal cancer (e.g., family history, personal history, or certain genetic conditions) or as part of routine screening if you’re due for a colonoscopy or have symptoms like changes in bowel habits.

Possible results include a normal finding, which usually means the measured values fall within the expected range, or an abnormal finding, which may suggest an infection, a chronic condition, or another issue that needs attention. Your provider will explain what your specific numbers mean and whether any follow-up testing is needed.

Results can be positive (indicating potential cancer or precancerous changes), negative (no detectable abnormalities), or inconclusive (requiring further testing). Follow-up may include additional tests like a colonoscopy to confirm findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Early Detection Matters

Short name

Stool Tumor DNA Screening

Frequently asked questions

Colorectal cancer often develops silently, so early detection through screening can help identify precancerous changes before they become advanced tumors. This test supports proactive cancer prevention and early intervention.
A positive result usually means the test detected the substance, organism, or condition it was designed to find. However, it does not always mean you are sick, so your provider may repeat the test or order additional testing to confirm the finding before discussing next steps with you.
A positive result suggests there may be abnormal cells in your stool, which could indicate colorectal cancer or precancerous polyps. Your doctor will discuss next steps, such as further testing like a colonoscopy, to investigate further.
How often you should have this test depends on your age, overall health, medical history, and the reason your provider ordered it. Some people need it once a year during a routine checkup, while others may need it more frequently, so ask your healthcare provider for a schedule tailored to your needs.
The frequency depends on your risk factors and healthcare provider recommendations. Generally, screening may be recommended every 1–3 years for average-risk individuals or more frequently for higher-risk patients.
Yes, you can eat and drink normally before collecting the stool sample. Follow the kit instructions for specific preparation guidelines, as some may recommend fasting or avoiding certain foods for 24 hours prior.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy