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Colorectal Cancer DNA Screening in Stool (Multiplex Polymerase Chain Reaction)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from colorectal cancer cells in your stool. It’s part of a screening to help detect early signs of cancer or precancerous changes.

Quick summary

["Early detection may improve treatment options and outcomes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77354-9
Short code
Noninv colon ca DNA+occ bld scrn Stl Ql
Synonyms
Noninv colon ca DNA+occ bld scrn Stl Ql
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

How the Test Works

Your stool sample is analyzed using advanced DNA testing to identify specific genetic markers linked to colorectal cancer. This method looks for mutations or changes in DNA that may indicate cancer risk, even when symptoms aren’t present.

What to Expect Before the Test

No special preparation is needed. Simply collect a small stool sample at home using the provided kit. Bring the sample to your lab or clinic on the day of testing.

What the Results Mean

If the test finds genetic markers associated with colorectal cancer, your healthcare provider will discuss next steps, which may include further testing or monitoring. False positives can occur, so results are always reviewed by a medical professional.

Possible Side Effects or Considerations

There are typically no side effects from this test. However, it’s important to follow up with your doctor if you notice any changes in bowel habits, blood in stool, or other concerning symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Stool DNA CRC Screening

Frequently asked questions

This test is designed to detect colorectal cancer DNA in stool samples, which can help identify precancerous polyps or early-stage cancer before symptoms appear. Early detection increases the chances of successful treatment and reduces the risk of complications.
This test is not a replacement for regular colonoscopies but is an additional screening option for people at average risk of colorectal cancer. Results should always be interpreted by a healthcare provider in the context of your overall health.
How often should I get this test?
The frequency depends on your risk factors. Your healthcare provider will recommend a schedule based on your age, family history, and personal health. Follow their guidance for the best results.
What if my test results are positive?
A positive result means further evaluation, such as a colonoscopy, may be needed to investigate further. Your doctor will explain the next steps and help you understand what to do.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy