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Urine Protein-to-Creatinine Ratio (24-hour collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the ratio of protein and creatinine in your urine over 24 hours to help assess how much protein your kidneys are losing.

Quick summary

["Helps detect kidney damage or proteinuria by quantifying urine protein loss relative to kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41284-1
Short code
Non-sq Epi Cells #/area UrnS HPF
Synonyms
Non-sq Epi Cells #/area UrnS HPF
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light-hpf
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, frequent urination, or unexplained fatigue, or if they suspect kidney problems. It’s also used to monitor kidney disease progression or response to treatment.

How the Test Works

You’ll collect all your urine over 24 hours in a special container. The lab then measures the protein and creatinine levels in your urine sample to calculate the ratio.

Sample Collection

To ensure accuracy, you’ll need to start and end the collection at the same time each day. Drink plenty of water but avoid foods that may affect urine protein levels (like salt or certain medications).

What to Expect

You’ll receive instructions on how to collect your urine sample at home. Some labs may provide a kit with a timer or other tools to help track your collection period.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A high ratio may indicate kidney damage, diabetes, or other conditions causing protein loss. A normal ratio suggests healthy kidney function, but repeated testing may still be needed for monitoring.

Short name

24-hour Urine Protein:Creatinine Ratio

Frequently asked questions

How long does the 24-hour urine collection take?
The collection period itself lasts about 24 hours, but you’ll need to follow specific instructions to ensure accurate results, including timing your sample collection precisely.
Can I eat or drink anything during the collection period?
Yes, but avoid foods or medications that might affect protein levels in your urine. Your doctor or lab will provide guidance on what to limit or avoid.
What if I miss part of the collection?
You’ll need to restart the collection immediately. Missing even a small portion can affect the test’s accuracy, so follow up with your healthcare provider right away.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy