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Free Normetanephrine and Creatinine, Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

Measures free normetanephrine, a catecholamine metabolite, along with creatinine in a serum or plasma blood sample.

Quick summary

["This test can help evaluate possible catecholamine-producing tumors and includes a creatinine measurement to help assess kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101176-6
Short code
Normetaneph Free/Creat SerPl-sRto
Synonyms
Normetaneph Free/Creat SerPl-sRto
Category
kidney
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

Free normetanephrine is a form of a catecholamine metabolite that is not attached to proteins. This test measures it in blood and may also report a creatinine measurement, which is commonly used to assess kidney function.

Why might I need this test?

Free normetanephrine is mainly tested when symptoms suggest a catecholamine-producing tumor, such as a pheochromocytoma or paraganglioma. These tumors can cause episodic high blood pressure, headaches, sweating, palpitations, or other symptoms.

How is the test performed?

A blood sample is collected by venipuncture. The serum or plasma is separated and analyzed in the laboratory using a validated testing method.

How do I prepare for the test?

Follow any instructions from your healthcare professional about fasting, resting before the draw, and avoiding strenuous exercise, because stress and activity can temporarily affect the result. Do not stop medications without medical guidance, although some medicines and substances may need to be discussed before testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Free normetanephrine with creatinine

Frequently asked questions

What does free normetanephrine measure?
It measures the unbound form of normetanephrine, a metabolite produced when the body breaks down catecholamines such as epinephrine and norepinephrine.
Does an abnormal result mean I have a tumor?
No. An elevated result can be caused by temporary physiologic factors, medications, or other conditions and may require repeat or confirmatory testing before a diagnosis is made.
Why is creatinine included?
Creatinine is commonly measured in blood to help evaluate kidney function. Its inclusion provides additional context when interpreting the overall laboratory report.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy