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Normetanephrine/Creatinine [Mass Ratio] in Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures normetanephrine relative to creatinine. It is commonly used to help screen for catecholamine-producing tumors.

Quick summary

["This test helps evaluate whether symptoms such as hypertension may be related to an adrenal or nervous-system tumor."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110395-1
Short code
Normetanephrine/Creat Msmt Ur
Synonyms
Normetanephrine/Creat Msmt Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Normetanephrine is a breakdown product of the hormone norepinephrine. This test measures the amount of normetanephrine in urine relative to urine creatinine, which helps account for differences in urine concentration.

Why might I need this test?

This test may be ordered to evaluate episodic or persistent hypertension, rapid heartbeat, sweating, severe headaches, or other symptoms that can occur with pheochromocytoma or paraganglioma tumors. It is usually part of a broader evaluation rather than a stand-alone diagnosis.

How is the test performed?

You provide a urine specimen, usually by a clean-catch collection. The laboratory measures normetanephrine and creatinine and calculates their ratio. If a timed collection is requested, follow the instructions for collecting all urine over the specified period.

How do I prepare for the test?

Follow your clinician's collection instructions and tell the laboratory about medicines, supplements, caffeine, alcohol, smoking, and recent exercise. Your care team may advise avoiding strenuous exercise and caffeine before collection, and will advise you if any medicines need to be adjusted. Do not stop prescribed medicines on your own.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine normetanephrine-to-creatinine ratio

Frequently asked questions

Does an abnormal result mean I have a tumor?
No. An elevated result suggests possible increased catecholamine production but can also result from stress, exercise, illness, or medications. Your clinician will interpret it with your symptoms, examination, and other tests.
Why is creatinine included in the test?
Creatinine helps account for how concentrated or dilute the urine sample is. The ratio makes normetanephrine measurements more comparable than a urine concentration alone.
Do I need to fast for this test?
Fasting is generally not required, but caffeine, nicotine, alcohol, and strenuous exercise may affect the result. Follow the specific preparation instructions provided by your clinician or laboratory.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy