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Serum or Plasma Creatinine Concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood. It helps assess how well your kidneys are filtering blood.

Quick summary

["A key measure of kidney function and filtering efficiency."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
34188-3
Short code
nRBC Bld Ql
Synonyms
nRBC Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine levels can indicate how well your kidneys are working. High levels may suggest kidney damage or disease, while low levels could be due to muscle loss or other conditions. Your doctor may order this test to monitor kidney health, especially if you have a history of kidney problems, diabetes, or high blood pressure.

How the Test Works

A small blood sample is taken from your arm. The lab then uses a specialized test to measure the creatinine concentration in your serum or plasma. The result helps determine how efficiently your kidneys remove waste products from your blood.

What to Expect Before the Test

You may not need any special preparation. However, if you’re taking certain medications (like some diuretics or contrast dyes for imaging), your doctor may advise you to avoid them before the test. Always follow your healthcare provider’s instructions.

Possible Results and Next Steps

Results are typically reported in milligrams per deciliter (mg/dL) or micromoles per liter (µmol/L). Your doctor will compare your result to your baseline or reference ranges to check for any changes. If your levels are unusually high, you may need further testing or treatment to manage kidney function.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: whole-blood

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a vital indicator of kidney function. Elevated levels often signal impaired kidney function, which can lead to complications like fluid buildup, electrolyte imbalances, or even heart problems. Regular monitoring helps detect kidney issues early and allows for timely medical intervention. Conversely, very low levels may warrant further investigation to rule out conditions like muscle wasting or dehydration.

Short name

Creatinine

Frequently asked questions

How often should I get this test?
Your doctor will determine how often you need this test based on your health history, current conditions, and overall medical needs. For example, people with diabetes, high blood pressure, or kidney disease may need it more frequently than others.
Can diet or exercise affect my creatinine levels?
Dietary changes, such as eating more protein, can temporarily affect creatinine levels. High-protein foods increase muscle breakdown, which may raise creatinine. Exercise can also influence muscle metabolism, but it’s usually temporary. Always discuss any changes with your doctor before interpreting results.
What if my test results are abnormal?
If your creatinine levels are higher than expected, your doctor may recommend additional tests, such as a kidney function panel or imaging studies, to investigate the cause. They may also adjust medications or treatments to support kidney health. If levels are low, further evaluation might be needed to rule out conditions like dehydration or muscle loss.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy