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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 17, 2026

This test measures a protein produced by the liver in response to inflammation, helping doctors assess low-level inflammation in your body.

Quick summary

["hs-CRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
70171-4
Short code
nRBC NFr Prt
Synonyms
nRBC NFr Prt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why hs-CRP Matters in Your Health

hs-CRP (high-sensitivity C-reactive protein) is a blood test that detects very small amounts of inflammation in your body. While inflammation is a normal part of healing, chronic or low-grade inflammation can be linked to conditions like heart disease, diabetes, and autoimmune disorders. This test is often used alongside other health checks to monitor risk or guide treatment decisions.

How the Test Works

Your blood sample is analyzed using a sensitive immunoassay method to detect CRP levels. The test measures the protein’s concentration in the blood, which can reflect ongoing inflammation even when symptoms aren’t present.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm for a blood draw, similar to other routine blood tests. If you’re taking blood thinners, let your healthcare provider know before the test.

Common Uses and Why It’s Ordered

Doctors may order hs-CRP to evaluate risk for cardiovascular diseases, monitor chronic conditions like arthritis or lupus, or check for signs of infection or inflammation after surgery or injury. It’s also used in research and screening programs to assess general health trends.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level suggests increased inflammation, which may indicate an underlying health issue like heart disease, autoimmune conditions, or chronic infections. Your doctor will consider your overall health, symptoms, and other test results to interpret the meaning of your results.
What does a low hs-CRP level mean?
A low hs-CRP level generally means your body’s inflammation is at a lower baseline. This could be normal, but your doctor may still recommend further testing if you have other risk factors or symptoms of inflammation.
Can hs-CRP levels change with lifestyle?
Yes, lifestyle factors like diet, exercise, smoking, and stress can influence inflammation levels. Making healthy choices—such as eating a balanced diet, staying active, and avoiding smoking—may help lower hs-CRP levels over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy