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Autoimmune Antibody Profile (Autoimmune Panel) – Serum

Published: August 9, 2026Updated: August 17, 2026

This test checks for antibodies that may indicate an autoimmune condition, where your body’s immune system mistakenly attacks healthy tissues. It helps identify potential causes of symptoms like fatigue, joint pain, or unexplained rashes.

Quick summary

["Helps diagnose or monitor autoimmune diseases by detecting abnormal immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
62438-7
Short code
nRBC # Snv Auto
Synonyms
nRBC # Snv Auto
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
automated-count
CPT
85041
SNOMED
900000000000003001
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What This Test Measures

This panel typically includes tests for several key antibodies, such as antinuclear antibodies (ANA), rheumatoid factor (RF), and others that may signal conditions like lupus, rheumatoid arthritis, or other autoimmune disorders. The exact antibodies tested can vary by lab, but it often screens for markers that target different organs or tissues in the body.

Common Conditions This Test May Help Identify

Positive results may suggest conditions like systemic lupus erythematosus (lupus), rheumatoid arthritis, Sjogren’s syndrome, or other autoimmune diseases. However, a single positive test does not confirm a diagnosis—additional testing and clinical correlation are needed.

How the Test Works

Blood is drawn and processed to separate serum, which is then analyzed using immunoassay methods (such as enzyme-linked immunosorbent assay, or ELISA). These tests detect the presence of specific antibodies in your serum that may indicate an autoimmune response.

Preparation and Sample Collection

No special preparation is usually required, but you may be asked to avoid certain medications or supplements for a few days before testing. A simple blood draw is performed in a clinic or lab, and the sample is sent for analysis.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: fluid

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Autoimmune Antibody Screen

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if you have symptoms like persistent fatigue, joint pain, unexplained rashes, or other signs of an autoimmune condition. It can also be used to monitor existing autoimmune diseases or check for new symptoms in people with a family history of autoimmune disorders.
What does a positive result mean?
A positive result means your blood contains antibodies that may signal an autoimmune response, but it does not definitively diagnose a condition. Follow-up testing and evaluation by a healthcare provider are necessary to determine the next steps.
Can I fast before this test?
No fasting is required for this test. However, always follow your healthcare provider’s instructions, as some tests may have specific guidelines depending on the exact panel being performed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy