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Serum or plasma concentration of total protein (mass concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Total protein levels can indicate overall health, hydration status, or potential medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
10477-8
Short code
NSE Ag Tiss Ql ImStn
Synonyms
NSE Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your healthcare provider may order this test to check for conditions like dehydration, kidney disease, liver problems, or certain infections. It can also help monitor long-term health, especially in people with chronic illnesses.

What to Expect

A small blood sample is taken from your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The test is quick and doesn’t require special preparation.

Common Conditions Monitored

Elevated total protein might suggest conditions like multiple myeloma, severe dehydration, or chronic infections. Low levels could indicate liver disease, kidney problems, or malnutrition.

Factors That Can Affect Results

Certain medications, pregnancy, or recent illness (like infections) can influence protein levels. Also, fasting or dehydration before the test may impact the results.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

How does total protein relate to my health?
Total protein is a broad measure that reflects your body’s protein balance. While it doesn’t pinpoint a single condition, it can signal systemic issues like fluid retention, organ dysfunction, or immune system challenges. Always discuss any changes with your provider.
Can I eat or drink before this test?
You may drink water but avoid eating for a few hours before your blood draw to get the most accurate results. Follow your provider’s specific instructions.
What if my protein levels are out of range?
If your results are abnormal, your provider will review them with you and may recommend further tests or treatments. This could include checking for kidney or liver function, infections, or other underlying causes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy