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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation or infection.

Quick summary

["hs-CRP helps track inflammation, which may signal underlying health concerns like heart disease or autoimmune conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
85098-2
Short code
NTBC DBS LC/MS/MS-sCnc
Synonyms
NTBC DBS LC/MS/MS-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lc-ms-ms
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why hs-CRP Matters

High-sensitivity CRP (hs-CRP) is a marker for low-grade inflammation in your body. It’s often used alongside other tests to assess risk for conditions like cardiovascular disease or to monitor treatment responses in chronic illnesses.

What to Expect During Testing

A blood sample is drawn from a vein, usually in your arm. The test is quick and typically done in a lab. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. No special preparation is needed unless instructed otherwise.

Common Uses

Doctors may order hs-CRP to evaluate risk for heart disease, monitor conditions like rheumatoid arthritis or lupus, or check for signs of infection or inflammation after surgery or illness.

When Results Might Be High or Low

Elevated hs-CRP levels may indicate inflammation, infections, or conditions like heart disease. Lower levels might suggest reduced inflammation, but they don’t always mean you’re healthy. Results depend on many factors, including age, health status, and medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level suggests inflammation is present in your body. While it doesn’t diagnose a specific condition, it can help guide treatment plans, especially for heart disease or autoimmune disorders. Always discuss results with your healthcare provider.
Can I lower my hs-CRP level?
Yes, lifestyle changes like improving diet, increasing physical activity, managing stress, and quitting smoking can help reduce inflammation and potentially lower hs-CRP levels. Your doctor may also recommend medications if needed.
Does hs-CRP change with age?
Yes, hs-CRP levels can vary with age. Older adults may naturally have slightly higher levels due to age-related inflammation. However, other factors like diet, exercise, and health conditions also play a role. Your results should be interpreted in the context of your overall health.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy